Supply High Quality of ABT-199 (1257044-40-8)

Supply High Quality of ABT-199 (1257044-40-8)
Product Details

M.Wt868.44StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
FormulaC₄₅H₅₀ClN₇O₇S
CAS No1257044-40-8
Solvent & Solubility

DMSO: ≥ 51 mg/mL

ABT-199 (GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1.

IC50 Value: <0.01 nM (Ki)
Target: Bcl-2 selective
ABT-199 is a potent and selective inhibitor of B-cell lymphoma-2 (BCL-2) family proteins, currently in clinical trials. ABT-199 inhibits the growth of BCL-2-dependent tumors in vivo and spares human platelets. A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24 h. These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers.

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